This site is for US animal healthcare professionals. Lucile Vigouroux holds a masters degree in Equine Performance, Health, and Welfare from Nottingham Trent University (UK) and an equine veterinary assistant certification from AAEVT. Oclacitinib is well tolerated and, compared with classic allergy medications such as glucocorticoids and cyclosporine, equally effective in controlling pruritus. No claims are made as to the safety or efficacy of mentioned preparations. This content is intended for counseling purposes only. This makes it a common site for the bodys expression of allergic reactions. Rosenkrantz WS, Bourgeois AS. Several reports of successful use of oclacitinib to treat other diseases have been published.22-29 They include several cases of immune-mediated vascular diseases: idiopathic ear tip vasculitis in 4 dogs26 and ischemic dermatopathy in 6 dogs.28,29 In these reports, other classic medications had failed to control the disease until oclacitinib was added. Merck & Co., Inc., Rahway, NJ, USA (known as MSD outside of the US and Canada) is dedicated to using the power of leading-edge science to save and improve lives around the world. I hear the result have been spectacular. Apoquel (oclacitinib tablet) Dosing & Administration How to dose Apoquel 0.4-0.6 mg/kg (0.18-0.27 mg/lb) Twice daily (BID) for up to 14 days Continue therapy once daily (SID) thereafter for maintenance May be given with or without food May discontinue without tapering Apoquel Dosing Guide Weight Range (lb) Number of Tablets to be Administered New Approach to Equine Asthma Treatment Stay up-to-date on the latest news about your horse's health with FREE newsletters from TheHorse.com. 27. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days. Vet Dermatol 2013;24(6):587-597, e141-142. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. All dogs itch sometimes, but when you notice it happening more and more, it could be a sign of a medical condition. The dose range is very strict, I do not recommend going above the recommended dose due to immune suppression, below the range and it doesn't seem to work in most cases. J Biol Chem 2007;282(28):20059-20063. Therefore, it is important to get your veterinarian involved right away. Apoquel for Dogs - Drugs.com It's typically prescribed twice daily for up to 14 days and then once daily after that. Apoquel reduces dog itch, and also decreases inflammation, redness, or swelling of the skinso your dog feels better as quickly as possible What is Apoquel Tablet? Drake GJ, Nuttall T, Lpez J, et al. Dosage options starting at $0.25 per dose. not random, very relevant and helpful! It is most risky in horses that have metabolic disease like Equine Metabolic Syndrome (insulin resistance), PPID (cushings), or those that are overweight. Since oclacitinib has been shown to be comparable to prednisolone, oclacitinib can be a good alternative to prednisolone when combined with cyclosporine for initial treatment. The tablets come in three dose sizes: 3.6mg 5.4mg 16mg Always give the dose prescribed by your veterinarian. Gonzales AJ, Humphrey WR, Messamore JE, et al. Cost is <$50/month, its easy, and its usually very effective. Option 3 is using a nebulizer with dexamethasone and/or other drugs. 16. Six adult horses with a mean weight of 528 kg were administered a single dose of 0.5 mg/kg oclacitinib maleate. Vet Dermatol 2015;26(4):235-e52. The innovative formula of the drug allows you . The bodys largest organ, the skin serves as the immune systems first protective barrier. Fortunately, these side effects are relatively uncommon. Apoquel should be shipped with extreme caution when temperature is below 35 degrees Fahrenheit. Because insects are omnipresent in the horses environment at least some portion of the year, IBH is particularly labor-intensive to manage. The dose of Apoquel tablets is 0.18 to 0.27 mg/lb of body weight. Dexamethasone for horses: Uses, Dosage & Side Effects - Wedgewood Pharmacy U.S. Food and Drug Administration Center for Veterinary Medicine 7500 Standish Place Rockville, MD 20855 www.fda.gov . Cosgrove SB, Wren JA, Cleaver DM, et al. Pet owners should visit ZoetisPetcare.com for product info, rewards and support. Blood was collected prior to drug administration and at 15 min, 30 min, 45 min, 1, 2, 4, 6, 8 . Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). Alternatively, your veterinarian may be able to show you some techniques. The drug is primarily used as a tranquilizer to calm anxious pets, especially dogs and horses, according to DailyMed. FREEDOM OF INFORMATION SUMMARY - Food and Drug Administration Dosage and Administration: The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. If you must give corticosteroids to an asthmatic horse, your veterinarian might prescribe them to be administered via an aerosol route through the nostril (rather than orally or via injection), which minimizes the amount that gets into the general circulation. Why Do Some Horses Develop Respiratory EHV-1 and Others EHM? Topics. Food allergies in particular you cant always do the serum for. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel) in client-owned dogs with atopic dermatitis. Apoquel is an anti-allergy drug that's often prescribed by vets. Submit Office Orders & Patient Prescriptions. Zyrtec: The human antihistamine may be beneficial in a small proportion of horses with Equine Asthma. Intradermal allergy testing is the gold standard for this and involves a veterinary dermatologist subcutaneously injecting very small quantities of potential allergens into a clipped patch of the horses neck. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. $ 78.30 - $ 245.00. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction. Apoquel | Horse and Hound Forum New Treatment Options for Your Dog's | FirstVet In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. The recommended dosage of Apoquel 3.6mg tablets is 0.18 to 0.27 milligrams per pound of body weight. Why were losing our horse doctors and how to begin solving the problem. Currently, White is part of a team evaluating the possibility of delivering allergy shots in the form of a juice squirted under the horses tongue. Really? We have been using an inflatable fleece e-collar on her . 3 Can be used for long-term maintenance or short-term therapy in dogs 12 months of age . In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days.7,8 Treatment success was based on reductions from baseline of at least 2 cm on the owner-assessed visual analog scale and at least 50% on the clinicians Canine Atopic Dermatitis Extent and Severity Index (CADESI-02). Diphenhydramine | VCA Animal Hospital - Veterinarians & Emergency Vets Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. 10. A blinded, randomized, placebo-controlled trial of the safety of No texts please., Horse breeding from planning through foal care, Horse-health-problem risk factors, prevention, diagnosis, and treatment, Design and maintain a healthy horse operation, Prevention and treatment for problems of the equine foot, How to care for the basic health needs of horses, Prevention, diagnosis, and treatment of leg lameness, Proper feeding practices for foals, adult horses, and older horses, All aspects of caring for performance horses, News and issues for equine health professionals, Discussions about the welfare of our equine friends. More severe ones, however, can truly take a toll on your horses health and make him miserable. Orthobiologic Options for Treating Horses. Search term . Apoquel is an anti-itch tablet given twice daily for the first . . A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. While oclacitinib is a very effective and fast-acting antipruritic drug, the decision of when to use it depends on various factors. If your horse's test results (from a BAL or tracheal wash) show a certain cell type in the lungs, we may recommend trying Zyrtec!Clenbuterol: This is a bronchodilator that may be beneficial in treating some horses with Equine Asthma. It can be given with or without food. Proc (Bayl Univ Med Cent) 2018;31(4):524-525. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. Pruritus is a common clinical sign in allergic skin diseases. Thats def not nothing but its not insane. 9. @stb its definitely not cheap. Collard WT, Hummel BD, Fielder AF, et al. So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. Insect and pollen season is here. Safety & Side Effects Apoquel is safe to use in dogs one year and older. 29. Vet Dermatol 2015;26:134 (abstract). Several reports of successful use of oclacitinib to treat other diseases have been published. The biggest disadvantages are the cost, the need to acclimate the horse to having the device placed in his or her nostril, poor tolerance by some horses who dislike the device, and the uncertainty about how long your horse will be able to go without repeating the treatment. Join us as we interview leading equine researchers from the University of Kentucky, Problem Solver Series: How to Control Nuisance Birds on Horse Properties. 17. This is a new treatment option, and currently the tablets are not FDA approved for horses, only dogs. To ensure that it's easy to administer the proper dosage to your dog, this treatment comes in three different dosages. If you mix it in their food, ensure that your pet chews the treatment rather than swallowing it without chewing for effective results. Oclacitinib in feline nonflea-, nonfood-induced hypersensitivity dermatitis: results of a small prospective pilot study of client-owned cats. This regimen may work better because oclacitinib has a short half-life of 4 hours. Oclacitinib can be given without food and may be discontinued without tapering. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. Despite its delayed effects, cyclosporine is still a popular drug to treat canine atopic dermatitis because in some cases it can be dosed every other day or even every third day after initial daily treatment. Apoquel Oclacitinib Used for Pet Meds MORE expand_more savings GoodRx lowest price $75.90 (Save -22%) local_offer Avg retail price $62.49 medication Availability Brand only Get 20% off your first order with code GOODRX20 Shop Apoquel at America's #1 Pet Pharmacy for the best pet prescription medications online!